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There are several matches for 'translation initiation factor 2'.
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7559 matches
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organism
protein
1)
Saccharomyces cerevisiae
IFM1 - Mitochondrial
translation
initiation
factor
2
.
[a.k.a. YOL023W, 854135, NM_001183277.1,
translation initiation factor 2
,
Translation initiation factor 2
, ...]
2)
Homo sapiens
EIF2AK3 - Eukaryotic
translation
initiation
factor
2
-alpha kinase 3; Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic
translation
initiation
factor
2
(eIF-2- alpha/EIF2S1) on 'Ser-52' during the unfolded protein response (UPR) and in response to low amino acid availability. Converts phosphorylated eIF-2-alpha/EIF2S1 either in a global protein synthesis inhibitor, leading to a reduced overall utilization of amino acids, or to a
translation
initiation
activator of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated [...]
[a.k.a. UPI0010893AAF, XM_017005376, ENST00000652736]
3)
Homo sapiens
EIF2S3 -
translation
initiation
factor
2
subunit 3; As a subunit of eukaryotic
initiation
factor
2
(eIF2), involved in the early steps of protein synthesis. In the presence of GTP, eIF2 forms a ternary complex with
initiator
tRNA Met-tRNAi and then recruits the 40S ribosomal complex, a step that determines the rate of protein
translation
. This step is followed by mRNA binding to form the 43S pre-
initiation
complex. Junction of the 60S ribosomal subunit to form the 80S
initiation
complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In o [...]
[a.k.a. R-HSA-72737, R-HSA-156827, R-HSA-72706]
4)
Homo sapiens
EIF4EBP2 - Eukaryotic
translation
initiation
factor
4E-binding protein
2
; Repressor of
translation
initiation
involved in synaptic plasticity, learning and memory formation (By similarity). Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress
translation
. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to
initiation
of
translation
. EIF4EBP2 is enriched in brain and acts as a regulator of s [...]
[a.k.a. ENST00000373218.4, uc001jrb.4, ENST00000373218]
5)
Homo sapiens
EIF2AK1 - Eukaryotic
translation
initiation
factor
2
-alpha kinase 1; Inhibits protein synthesis at the
translation
initiation
level, in response to various stress conditions, including oxidative stress, heme deficiency, osmotic shock and heat shock. Exerts its function through the phosphorylation of EIF2S1 at 'Ser-48' and 'Ser- 51', thus preventing its recycling. Binds hemin forming a 1:1 complex through a cysteine thiolate and histidine nitrogenous coordination. This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell. Thanks to this unique heme-se [...]
[a.k.a. ENSP00000392459, ENST00000463213.5, UPI000173A260]
6)
Homo sapiens
EIF2AK4 - eIF-2-alpha kinase GCN2; Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic
translation
initiation
factor
2
(eIF-2- alpha/EIF2S1) on 'Ser-52' in response to low amino acid availability. Plays a role as an activator of the integrated stress response (ISR) required for adapatation to amino acid starvation. Converts phosphorylated eIF-2-alpha/EIF2S1 either to a competitive inhibitor of the
translation
initiation
factor
eIF-2B, leading to a global protein synthesis repression, and thus to a reduced overall utilization of amino acids, or to a transla [...]
[a.k.a. ENST00000559032.1, URS00008B9903, ENST00000316599]
7)
Homo sapiens
EIF2S2 -
translation
initiation
factor
2
subunit
2
; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and
initiator
tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S
initiation
complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of
initiation
, the GDP bound to eIF-2 must exchange with GTP by way of a reaction
[a.k.a. EIF2beta, R-HSA-72737, Q9BVU0]
8)
Homo sapiens
EIF4E2 - Eukaryotic
translation
initiation
factor
4E type
2
; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the
initiation
. Acts as a repressor of
translation
initiation
. In contrast to EIF4E, it is unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggesting that it acts by competing with EIF4E and block assembly of eIF4F at the cap (By similarity).
[a.k.a. ENST00000479834, EIF4E2-204, ENST00000459714.1]
9)
Homo sapiens
EIF3G - Eukaryotic
translation
initiation
factor
3 subunit G; RNA-binding component of the eukaryotic
translation
initiation
factor
3 (eIF-3) complex, which is required for several steps in the
initiation
of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-
2
:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-
initiation
complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termi [...]
[a.k.a. R-HSA-72737, AAC78728.1, eIF3-delta]
10)
Homo sapiens
EIF3CL - Eukaryotic
translation
initiation
factor
3 subunit C-like protein; Component of the eukaryotic
translation
initiation
factor
3 (eIF-3) complex, which is required for several steps in the
initiation
of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-
2
:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-
initiation
complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-term [...]
[a.k.a. ENST00000398944, NP_001304786.1, B5ME19]
11)
Homo sapiens
EIF2B2 -
Translation
initiation
factor
eIF-2B subunit beta; Catalyzes the exchange of eukaryotic
initiation
factor
2
- bound GDP for GTP; Belongs to the eIF-2B alpha/beta/delta subunits family.
[a.k.a. R-HSA-72737, EIF-2Bbeta, BC011750]
12)
Homo sapiens
EIF2B3 -
Translation
initiation
factor
eIF-2B subunit gamma; Catalyzes the exchange of eukaryotic
initiation
factor
2
- bound GDP for GTP; Belongs to the eIF-2B gamma/epsilon subunits family.
[a.k.a. R-HSA-72737, XM_017002745.2, eIF-2B GDP-GTP exchange factor subunit gamma]
13)
Homo sapiens
EIF2B1 -
Translation
initiation
factor
eIF-2B subunit alpha; Catalyzes the exchange of eukaryotic
initiation
factor
2
- bound GDP for GTP.
[a.k.a. R-HSA-72737, AAI03764.1, eIF-2B GDP-GTP exchange factor subunit alpha]
14)
Homo sapiens
EIF2B4 -
Translation
initiation
factor
eIF-2B subunit delta; Catalyzes the exchange of eukaryotic
initiation
factor
2
- bound GDP for GTP.
[a.k.a. NM_001318969.1, R-HSA-72737, NM_172195.3]
15)
Homo sapiens
EIF2B5 -
Translation
initiation
factor
eIF-2B subunit epsilon; Catalyzes the exchange of eukaryotic
initiation
factor
2
- bound GDP for GTP; Belongs to the eIF-2B gamma/epsilon subunits family.
[a.k.a. R-HSA-72737, ENSP00000498164, ENST00000648890]
16)
Homo sapiens
EIF2S1 -
translation
initiation
factor
2
subunit 1; Functions in the early steps of protein synthesis by forming a ternary complex with GTP and
initiator
tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-
initiation
complex. Junction of the 60S ribosomal subunit to form the 80S
initiation
complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of
initiation
, the GDP bound to eIF-
2
must exchange with GTP by way of a reaction
[a.k.a. R-HSA-72737, ENST00000555876, ENSG00000134001]
17)
Homo sapiens
EIF2S3B - Eukaryotic
translation
initiation
factor
2
subunit gamma B.
[a.k.a. eIF-2-gamma2, ENST00000322446, CCDS86282.1]
18)
Homo sapiens
EIF4G2 - Eukaryotic
translation
initiation
factor
4 gamma
2
; Appears to play a role in the switch from cap-dependent to IRES-mediated
translation
during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases.
[a.k.a. 3D3M, Q2NKW9, EIF4G2-225]
19)
Homo sapiens
GIGYF2 - GRB10-interacting GYF protein
2
; Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of
translation
initiation
. In 4EHP-GYF2 the complex, acts as a
factor
that bridges EIF4E2 to ZFP36/TTP, linking
translation
repression with mRNA decay (By similarity). May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors ; Belongs to the GIGYF family.
[a.k.a. ENSP00000362664, CCDS46542, NR_103492.1]
20)
Mus musculus
Eif2ak3 - Eukaryotic
translation
initiation
factor
2
-alpha kinase 3; Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic
translation
initiation
factor
2
(eIF-2- alpha/EIF2S1) on 'Ser-52' during the unfolded protein response (UPR) and in response to low amino acid availability. Converts phosphorylated eIF-2-alpha/EIF2S1 either in a global protein synthesis inhibitor, leading to a reduced overall utilization of amino acids, or to a
translation
initiation
activator of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated [...]
[a.k.a. XP_011239504.1, NP_034251, R-MMU-392499]
7559 matches
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